This Department of Pharmacology is where Siddha drugs are primarily subjected to toxicity studies for acute, sub-acute and chronic phases with an objective to study the drugs for toxic effects if any and their influences in different biological systems. As such various experimental pharmacological techniques are being employed for evaluating the different aspects of drug effects/efficacy evaluation.
Since inception this department has undertaken 150 drugs formulation along with several Ayurvedic drugs allotted by the council and several isolates for Caption Srinivasamoorthy Drug Research Institute for Ayurveda, Chennai for pharmacological activities with special reference to toxic effects. At present this department is involved in the pre clinical toxicological and pharmacological studies of Siddha as well as Ayurvedic drugs also. This department has so far carried out more than two hundred pharmacological and toxicity studies such as: Anti-malarial, Hepatoprotectant/ hepato curative, Antipyretic, anti-arthritic, Antifertility Immunomodulatory, anti-inflammatory Anti stress, Anti-ulcerative, Wound healing, Analgesic, Anticonvulsant, Diuretic, Ant diabetic, CNS activity (Rota-rod, cook’s pole climbing apparatus, actophotometer), anticancer, acute toxicity, sub acute toxicity, chronic toxicity, etc.
LABORATORY ANIMAL HOUSE FACILITY:
To cater the need of laboratory animals like albino rats and mice the department has established laboratory animal house in 1973. As per CPCSEA (Committee for the purpose of control and supervision on experiments on animals) guidelines for animal facility, registration (Reg.No.512/01/CPCSEA) had been approved for carrying out the experiments in 2001. The animals are scientifically bred on different scientific lines to provide animals for research with least possible variations.
PHARMACOLOGICAL AND TOXICOLOGICAL RESEARCH STUDIES CARRIEDOUT IN CRIS
Acute toxicity : 112
Sub-acute toxicity : 29
Chronic toxicity : 8
Anti-inflammatory : 40
Analgesic : 19
Anti-pyretic : 10
Anti-arthritic : 9
Anti-fertility : 7
Hypoglycaemic : 6
Diuretic : 3
Hypothermic : 3
Hepatoprotective : 4
Nephroprotective : 3
Anti-ulcer : 1
Haemostatic : 1
Anti-fungal : 1
Anti-spasmodic : 1
Oestrogenic :1
LIST OF INSTRUMENTS AVAILABLE IN THE DEPARTMENT:
Electro convulsiometer
Eddy’s Hot plate
Hot air oven
Hot Plate – ordinary
Haemometer
Incubator
Operation table
Digital Plethysmograph
pH meter
Refrigerator
Cook’s Pole climbing Apparatus
Rota-rod Apparatus
Actophotometer
Digital Plethysmometer
ACHIEVEMENTS OF THE DEPARTMENT:
No. of Siddha drugs subjected for various pharmacological studies-150
Experimental pharmacological studies of 777 oil, Triphala, Rasagandhi mezhugu (RGX), SKX, VK2 Laksha, Ayush AC-IV etc.
Herbo-mineral drugs (15) were subjected for experimental pharmacological studies.
Confirmation of nontoxic nature of 11-metalic drugs like mercury and copper subjected for long-term toxicology studies in animals.
Research awards: B.Mukerjee prize by I.P.S. in 1986 and CCRAS Research award in 1991-92.
PCT PROJECT:
Toxicity studied allotted: Acute, Sub-acute and Chronic toxicity
Status of Project: Completed
RCH PROJECT:
Toxicity studied allotted: Acute and Sub-acute toxicity
Status of Project: Completed:
IN-HOUSE PROJECT:
Therapeutic efficacy and toxicity studies of Nandhi mezhugu and Cancergajkesari in 7-12 dimethyl benzanthracene (DMBA) induced mammary tumours in rats in collaboration with Department of Pathology, Madras Veterinary College.
Status of Project: completed
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